55. Ulusal Nöroloji Kongresi

NOROKONGRE 2019


 
SİGNAL İNTENSİTY CHANGES İN THE DENTATE NUCLEUS AND GLOBUS PALLİDUS OF MULTİPLE SCLEROSİS PATİENTS AFTER SERİAL NUMBER OF CRANİAL MAGNETİC RESONANCE İMAGİNG EXAMİNATİONS WİTH GADOLİNİUM BASED CONTRAST AGENTS
YASİN ERTUĞ ÇEKDEMİR 1 NURİ KARABAY 1

1- DOKUZ EYLÜL ÜNİVERSİTESİ
 
Amaç:

To investigate whether there was a correlation between cumulative doses of gadolinium-based contrast agents and increased signal intensity in the dentate nucleus and globus pallidus.

Gereç ve Yöntem:

This retrospective trial involved 21 multiple sclerosis patients (11 women, 10 men; average age: 39.21±10.24, range: 20 to 57) who underwent a serial number of multiple cranial magnetic resonance imaging (MRI) examinations in the radiology department of our tertiary care center. Average signal intensities on the dentate nucleus, pons, globus pallidus and thalamus on unenhanced T1-weighted magnetic resonance images were taken into account. The signal intensity in the dentate nucleus was divided to the signal intensity in the pons, whereas the signal intensity in globus pallidus was divided to the signal intensity in the thalamus. Any relationship between the dentate nucleus-to-pons or globus pallidus-to-thalamus signal ratios and previous gadolinium-based contrast administrations were sought by means of repeated measures ANOVA.

Bulgular:

Both dentate nucleus-to-pons and globus pallidus-to-thalamus ratios displayed a significant correlation with previous administrations of gadolinium-based contrast agents (p<0.001 for both). There was a remarkable increase in dentate nucleus-to-pons and globus pallidus-to-thalamus signal ratios at first and last MRI examinations (p<0.001 for both).

Sonuç:

To conclude, our results support the association between high signal intensity of the dentate nucleus and globus pallidus to the number of gadolinium-enhanced MRI scans in MS patients. The increase in T1 signal intensity seems to be linked with the number of enhanced MRI scans.